Genetic Analysis of Tryptophan Metabolism Genes in Sporadic Amyotrophic Lateral Sclerosis

Genetic Analysis of Tryptophan Metabolism Genes in Sporadic Amyotrophic Lateral Sclerosis

The essential amino acid tryptophan (TRP) is the initiating metabolite of the kynurenine pathway (KP), which can be upregulated by inflammatory conditions in cells. Neuroinflammation-triggered activation of the KP and excessive production of the KP metabolite quinolinic acid are common features of m...

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Bibliographic Details
Main Authors: Jennifer A. Fifita, Sandrine Chan Moi Fat, Emily P. McCann, Kelly L. Williams, Natalie A. Twine, Denis C. Bauer, Dominic B. Rowe, Roger Pamphlett, Matthew C. Kiernan, Vanessa X. Tan, Ian P. Blair, Gilles J. Guillemin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
sporadic amyotrophic lateral sclerosis (SALS)
whole-genome sequence (WGS)
tryptophan
kynurenine pathway (KP)
serotonin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.701550/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.701550/full

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