Repurposing Cholinesterase Inhibitors as Antidepressants? Dose and Stress-Sensitivity May Be Critical to Opening Possibilities

When stress becomes chronic it can trigger lasting brain and behavioral changes including Major Depressive Disorder (MDD). There is conflicting evidence regarding whether acetylcholinesterase inhibitors (AChEIs) may have antidepressant properties. In a recent publication, we demonstrated a strong do...

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Bibliographic Details
Main Authors: Paul J. Fitzgerald, Pho J. Hale, Anjesh Ghimire, Brendon O. Watson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2020.620119/full