HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread

Summary: Trafficking of cell-associated HIV-1 from the genital mucosa to lymphoid organs represents a critical first step toward systemic infection. Mature DCs capture and transmit HIV-1 to T cells, but insights into DC-to-T cell viral spread dynamics within a 3-dimensional environment is lacking. U...

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Bibliographic Details
Main Authors: Wan Hon Koh, Paul Lopez, Oluwaseun Ajibola, Roshan Parvarchian, Umar Mohammad, Ryan Hnatiuk, Jason Kindrachuk, Thomas T. Murooka
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306179