PKCδ sensitizes neuroblastoma cells to L-buthionine-sulfoximine and etoposide inducing reactive oxygen species overproduction and DNA damage.

PKCδ sensitizes neuroblastoma cells to L-buthionine-sulfoximine and etoposide inducing reactive oxygen species overproduction and DNA damage.

Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to chemotherapy and radiation is inhibited by the presence of antioxidants, such as glutathione (GSH), which is crucial in counteracting the endogenous production of reactive oxygen species (ROS). We have...

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Bibliographic Details
Main Authors: Barbara Marengo, Chiara De Ciucis, Roberta Ricciarelli, Mario Passalacqua, Mariapaola Nitti, Jean-Marc Zingg, Umberto M Marinari, Maria A Pronzato, Cinzia Domenicotti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3034714?pdf=render

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http://europepmc.org/articles/PMC3034714?pdf=render

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