The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry.

The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry.

During the process of HIV-1 fusion with the target cell, the N-terminal heptad repeat (NHR) of gp41 interacts with the C-terminal heptad repeat (CHR) to form fusogenic six-helix bundle (6-HB) core. We previously identified a crucial residue for 6-HB formation and virus entry--Lys63 (K63) in the C-te...

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Bibliographic Details
Main Authors: Xiaoyi Wang, Weiliang Xiong, Xiaochu Ma, Meili Wei, Yanxia Chen, Lu Lu, Asim K Debnath, Shibo Jiang, Chungen Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22970321/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22970321/?tool=EBI

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