A novel CRISPR-based malaria diagnostic capable of Plasmodium detection, species differentiation, and drug-resistance genotyping

A novel CRISPR-based malaria diagnostic capable of Plasmodium detection, species differentiation, and drug-resistance genotyping

Background: CRISPR-based diagnostics are a new class of highly sensitive and specific assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific High-Sensitivity Enzymatic Reporter UnLOCKing, is one such CRISPR-based diagnostic that combines recombinase polymerase pre-a...

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Bibliographic Details
Main Authors: Clark H. Cunningham, Christopher M. Hennelly, Jessica T. Lin, Ratawan Ubalee, Ross M. Boyce, Edgar M. Mulogo, Nicholas Hathaway, Kyaw L. Thwai, Fernandine Phanzu, Albert Kalonji, Kashamuka Mwandagalirwa, Antoinette Tshefu, Jonathan J. Juliano, Jonathan B. Parr
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:EBioMedicine
Subjects:
SHERLOCK
Malaria
CRISPR
Cas13a
Diagnostic
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421002085

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http://www.sciencedirect.com/science/article/pii/S2352396421002085

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