Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer’s Disease

Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer’s Disease

Alzheimer’s disease (AD) prevalence varies by sex, suggesting that sex chromosomes, sex hormones and/or their signaling could potentially modulate AD risk and progression. Low testosterone levels are reported in men with AD. Further, variation in the androgen receptor (AR) gene has been associated w...

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Bibliographic Details
Main Authors: Jessie S. Carr, Luke W. Bonham, Alicia K. Morgans, Charles J. Ryan, Jennifer S. Yokoyama, Ethan G. Geier, Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
androgen receptor
testosterone
steroid
biomarker
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00529/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00529/full

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