Ultra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparative ex vivo and in vivo studies

Ultra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparative ex vivo and in vivo studies

Fenticonazole nitrate (FTN) is a potent antifungal drug adopted in the treatment of vaginal candidiasis. It has inadequate aqueous solubility hence, novel ultra-deformable liposomes ‘Terpesomes’ (TPs) were developed that might prevail over FTN poor solubility besides TPs might abstain the obstacles...

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Bibliographic Details
Main Authors: Rofida Albash, Yasmina Elmahboub, Kholoud Baraka, Menna M. Abdellatif, Ahmed Adel Alaa-Eldin
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
box behnken design
fenticonazole nitrate
microbiological study
ultra-deformable liposomes
terpesomes
vaginal drug delivery
Online Access:http://dx.doi.org/10.1080/10717544.2020.1837295

Internet

http://dx.doi.org/10.1080/10717544.2020.1837295

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