Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis
Tertiary lymphoid structures (TLSs) develop in non-lymphatic tissue in chronic inflammation and cancer. TLS can mature to lymph node (LN) like structures with germinal centers and associated vasculature. TLS neogenesis in cancer is highly varied and tissue dependent. The role of TLS in adaptive anti...
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doaj-10cdac77ab794d19a943d8ee654079de2021-09-08T04:52:35ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-09-01810.3389/fmolb.2021.661516661516Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in MetastasisRami Mustapha0Rami Mustapha1Kenrick Ng2Kenrick Ng3James Monypenny4Tony Ng5Tony Ng6Tony Ng7Tony Ng8Richard Dimbleby Laboratory of Cancer Research, School of Cancer and Pharmaceutical Sciences, King’s College London, Guy’s Medical School Campus, London, United KingdomCancer Research UK King’s Health Partners Centre, London, United KingdomUCL Cancer Institute, University College London, London, United KingdomDepartment of Medical Oncology, University College Hospitals NHS Foundation Trust, London, United KingdomRichard Dimbleby Laboratory of Cancer Research, School of Cancer and Pharmaceutical Sciences, King’s College London, Guy’s Medical School Campus, London, United KingdomRichard Dimbleby Laboratory of Cancer Research, School of Cancer and Pharmaceutical Sciences, King’s College London, Guy’s Medical School Campus, London, United KingdomCancer Research UK City of London Centre, London, United KingdomUCL Cancer Institute, University College London, London, United KingdomCancer Research UK King’s Health Partners Centre, London, United KingdomTertiary lymphoid structures (TLSs) develop in non-lymphatic tissue in chronic inflammation and cancer. TLS can mature to lymph node (LN) like structures with germinal centers and associated vasculature. TLS neogenesis in cancer is highly varied and tissue dependent. The role of TLS in adaptive antitumor immunity is of great interest. However, data also show that TLS can play a role in cancer metastasis. The importance of lymphatics in cancer distant metastasis is clear yet the precise detail of how various immunosurveillance mechanisms interplay within TLS and/or draining LN is still under investigation. As part of the tumor lymphatics, TLS vasculature can provide alternative routes for the establishment of the pre-metastatic niche and cancer dissemination. The nature of the cytokine and chemokine signature at the heart of TLS induction can be key in determining the success of antitumor immunity or in promoting cancer invasiveness. Understanding the biochemical and biomechanical factors underlying TLS formation and the resulting impact on the primary tumor will be key in deciphering cancer metastasis and in the development of the next generation of cancer immunotherapeutics.https://www.frontiersin.org/articles/10.3389/fmolb.2021.661516/fullTLSmetastasispremetastatic nichehigh endothelial venule (HEV)lymphangiogeneistissue stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rami Mustapha Rami Mustapha Kenrick Ng Kenrick Ng James Monypenny Tony Ng Tony Ng Tony Ng Tony Ng |
spellingShingle |
Rami Mustapha Rami Mustapha Kenrick Ng Kenrick Ng James Monypenny Tony Ng Tony Ng Tony Ng Tony Ng Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis Frontiers in Molecular Biosciences TLS metastasis premetastatic niche high endothelial venule (HEV) lymphangiogeneis tissue stress |
author_facet |
Rami Mustapha Rami Mustapha Kenrick Ng Kenrick Ng James Monypenny Tony Ng Tony Ng Tony Ng Tony Ng |
author_sort |
Rami Mustapha |
title |
Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis |
title_short |
Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis |
title_full |
Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis |
title_fullStr |
Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis |
title_full_unstemmed |
Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis |
title_sort |
insights into unveiling a potential role of tertiary lymphoid structures in metastasis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Molecular Biosciences |
issn |
2296-889X |
publishDate |
2021-09-01 |
description |
Tertiary lymphoid structures (TLSs) develop in non-lymphatic tissue in chronic inflammation and cancer. TLS can mature to lymph node (LN) like structures with germinal centers and associated vasculature. TLS neogenesis in cancer is highly varied and tissue dependent. The role of TLS in adaptive antitumor immunity is of great interest. However, data also show that TLS can play a role in cancer metastasis. The importance of lymphatics in cancer distant metastasis is clear yet the precise detail of how various immunosurveillance mechanisms interplay within TLS and/or draining LN is still under investigation. As part of the tumor lymphatics, TLS vasculature can provide alternative routes for the establishment of the pre-metastatic niche and cancer dissemination. The nature of the cytokine and chemokine signature at the heart of TLS induction can be key in determining the success of antitumor immunity or in promoting cancer invasiveness. Understanding the biochemical and biomechanical factors underlying TLS formation and the resulting impact on the primary tumor will be key in deciphering cancer metastasis and in the development of the next generation of cancer immunotherapeutics. |
topic |
TLS metastasis premetastatic niche high endothelial venule (HEV) lymphangiogeneis tissue stress |
url |
https://www.frontiersin.org/articles/10.3389/fmolb.2021.661516/full |
work_keys_str_mv |
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