Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice

Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice

Abstract Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of Go in the developing cerebellar cortex by deletin...

Full description

Bibliographic Details
Main Authors: Hye Lim Cha, Jung-Mi Choi, Huy-Hyen Oh, Narayan Bashyal, Sung-Soo Kim, Lutz Birnbaumer, Haeyoung Suh-Kim
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Brain
Subjects:
Go alpha subunit (Gαo
GTP-binding protein alpha subunit of Go)
Purkinje cell
Cerebellum
Hypoplasia
Synaptic boutons
Online Access:http://link.springer.com/article/10.1186/s13041-019-0477-9

Internet

http://link.springer.com/article/10.1186/s13041-019-0477-9

Similar Items