Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism

Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism

The anti-Parkinson monoamine oxidase (MAO)-B inhibitor rasagiline (Azilect) was shown to possess neuroprotective activities, involving the induction of brain-derived- and glial cell line-derived neurotrophic factors (BDNF, GDNF). Employing conventional neurochemical techniques, transcriptomics and p...

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Bibliographic Details
Main Authors: Yotam Sagi, Silvia Mandel, Tamar Amit, Moussa B.H. Youdim
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Neurobiology of Disease
Subjects:
Rasagiline
Monoamine oxidase
MPTP
Neurorescue
Transcriptomics
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002063

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http://www.sciencedirect.com/science/article/pii/S0969996106002063

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