Challenges and Advances in Antemortem Diagnosis of Human Transmissible Spongiform Encephalopathies

Challenges and Advances in Antemortem Diagnosis of Human Transmissible Spongiform Encephalopathies

Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, arise from the structural conversion of the monomeric, cellular prion protein (PrPC) into its multimeric scrapie form (PrPSc). These pathologies comprise a group of intractable, rapidly evolving neurodegenerative disease...

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Bibliographic Details
Main Authors: Lucas M. Ascari, Stephanie C. Rocha, Priscila B. Gonçalves, Tuane C. R. G. Vieira, Yraima Cordeiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
prion diseases
prion protein
diagnostic
cell-free conversion assay
neurodegenerative disease
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.585896/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2020.585896/full

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