Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure

Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure

Abstract Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer’s disease (AD) and other neurological conditions with prominent astrogliosis. AQP4 redistribution has been propos...

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Bibliographic Details
Main Authors: Alex J. Smith, Tianjiao Duan, Alan S. Verkman
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Acta Neuropathologica Communications
Subjects:
Astroglia
Water channel
Neurodegeneration
Glial barrier
Online Access:http://link.springer.com/article/10.1186/s40478-019-0728-0

Internet

http://link.springer.com/article/10.1186/s40478-019-0728-0

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