Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion

Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion

Cytomegaloviruses (CMVs) are ubiquitous pathogens known to employ numerous immunoevasive strategies that significantly impair the ability of the immune system to eliminate the infected cells. Here, we report that the single mouse CMV (MCMV) protein, m154, downregulates multiple surface molecules inv...

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Bibliographic Details
Main Authors: Ivana Strazic Geljic, Paola Kucan Brlic, Guillem Angulo, Ilija Brizic, Berislav Lisnic, Tina Jenus, Vanda Juranic Lisnic, Gian Pietro Pietri, Pablo Engel, Noa Kaynan, Jelena Zeleznjak, Peter Schu, Ofer Mandelboim, Astrid Krmpotic, Ana Angulo, Stipan Jonjic, Tihana Lenac Rovis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
immune evasion
cytomegalovirus, CMV
PVR, CD155
m154 protein
adaptor protein-1, AP-1
CD8+ T cells
Online Access:https://elifesciences.org/articles/50803

Internet

https://elifesciences.org/articles/50803

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