Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

Frontotemporal dementia (FTD) and other tauopathies characterized by focal brain neurodegeneration and pathological accumulation of proteins are commonly associated with tau mutations. However, the mechanism of neuronal loss is not fully understood. To identify molecular events associated with tauop...

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Bibliographic Details
Main Authors: M. Catarina Silva, Chialin Cheng, Waltraud Mair, Sandra Almeida, Helen Fong, M. Helal U. Biswas, Zhijun Zhang, Yadong Huang, Sally Temple, Giovanni Coppola, Daniel H. Geschwind, Anna Karydas, Bruce L. Miller, Kenneth S. Kosik, Fen-Biao Gao, Judith A. Steen, Stephen J. Haggarty
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116301515

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http://www.sciencedirect.com/science/article/pii/S2213671116301515

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