ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts.

ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts.

BACKGROUND:Temozolomide (TMZ) is active against glioblastomas (GBM) in which the O6-methylguanine-DNA methyltransferase (MGMT) gene is silenced. However, even in responsive cases, its beneficial effect is undermined by the emergence of drug resistance. Here, we tested whether inhibition of poly (ADP...

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Bibliographic Details
Main Authors: Alice L Yuan, Christian B Ricks, Alexandra K Bohm, Xueqing Lun, Lori Maxwell, Shahana Safdar, Shazreh Bukhari, Amanda Gerber, Wajid Sayeed, Elizabeth A Bering, Haley Pedersen, Jennifer A Chan, Yaoqing Shen, Marco Marra, David R Kaplan, Warren Mason, Lindsey D Goodman, Ravesanker Ezhilarasan, Ascher B Kaufmann, Matthew Cabral, Steve M Robbins, Donna L Senger, Daniel P Cahill, Erik P Sulman, J Gregory Cairncross, Michael D Blough
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6112648?pdf=render

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http://europepmc.org/articles/PMC6112648?pdf=render

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