Relevance of PSGL-1 Expression in B Cell Development and Activation

Relevance of PSGL-1 Expression in B Cell Development and Activation

PSGL-1 is expressed in all plasma cells, but only in a small percentage of circulating B cells. Patients with systemic sclerosis (SSc) show reduced expression of PSGL-1 in B cells and increased prevalence of pulmonary arterial hypertension. PSGL-1 deficiency leads to a SSc-like syndrome and SSc-asso...

Full description

Bibliographic Details
Main Authors: Rafael González-Tajuelo, Elena González-Sánchez, Javier Silván, Antonio Muñoz-Callejas, Esther Vicente-Rabaneda, Javier García-Pérez, Santos Castañeda, Ana Urzainqui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
PSGL-1 (CD162)
B cells
development
activation
pulmonary arterial hypertension
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.588212/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.588212/full

Similar Items