PTK7-Targeting CAR T-Cells for the Treatment of Lung Cancer and Other Malignancies

PTK7-Targeting CAR T-Cells for the Treatment of Lung Cancer and Other Malignancies

In spite of impressive success in treating hematologic malignancies, adoptive therapy with chimeric antigen receptor modified T cells (CAR T) has not yet been effective in solid tumors, where identification of suitable tumor-specific antigens remains a major obstacle for CAR T-cell therapy due to th...

Full description

Bibliographic Details
Main Authors: Yamin Jie, Guijun Liu, Lina Feng, Ying Li, Mingyan E, Liangliang Wu, Yinyin Li, Guanghua Rong, Yongwu Li, Huafeng Wei, Anxin Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor (CAR)
cancer stem cells (CSCs)
lung cancer 4
adoptive cell therapy (ACT)
tumor-initiating cells (TICs)
PTK7
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.665970/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.665970/full

Similar Items