Knotting and unknotting proteins in the chaperonin cage: Effects of the excluded volume.

Molecular dynamics simulations are used to explore the effects of chaperonin-like cages on knotted proteins with very low sequence similarity, different depths of a knot but with a similar fold, and the same type of topology. The investigated proteins are VirC2, DndE and MJ0366 with two depths of a...

Full description

Bibliographic Details
Main Authors: Szymon Niewieczerzal, Joanna I Sulkowska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5425179?pdf=render