Augmenting the Immune Response against a Stabilized HIV-1 Clade C Envelope Trimer by Silica Nanoparticle Delivery

Augmenting the Immune Response against a Stabilized HIV-1 Clade C Envelope Trimer by Silica Nanoparticle Delivery

The delivery of HIV-1 envelope (Env) trimer-based immunogens on the surface of nanoparticles holds promise to promote immunogenicity with the aim of inducing a potent, durable and broad neutralizing antibody (bnAb) response. Towards that goal, we examined the covalent conjugation of Env to 100 nm an...

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Bibliographic Details
Main Authors: David Peterhoff, Stefanie Thalhauser, Jan M. Sobczak, Mona O. Mohsen, Christoph Voigt, Nicole Seifert, Patrick Neckermann, Alexandra Hauser, Song Ding, Quentin Sattentau, Martin F. Bachmann, Miriam Breunig, Ralf Wagner
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Vaccines
Subjects:
HIV vaccine
silica nanoparticles
stabilized envelope trimer
Env
Online Access:https://www.mdpi.com/2076-393X/9/6/642

Internet

https://www.mdpi.com/2076-393X/9/6/642

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