Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice.

Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice.

Modulation of chemokine CXCL12 and its receptor CXCR4 has been implicated in attenuation of bleomycin (BLM)-induced pulmonary fibrosis and carbon tetrachloride (CCl4)-induced hepatic injury. In pulmonary fibrosis, published reports suggest that collagen production in the injured lung is derived from...

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Bibliographic Details
Main Authors: Leola N Chow, Petra Schreiner, Betina Y Y Ng, Bernard Lo, Michael R Hughes, R Wilder Scott, Vionarica Gusti, Samantha Lecour, Eric Simonson, Irina Manisali, Ingrid Barta, Kelly M McNagny, Jason Crawford, Murray Webb, T Michael Underhill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4801399?pdf=render

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http://europepmc.org/articles/PMC4801399?pdf=render

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