PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

Abstract Background d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical for the proliferation or homeostasis of tissues following the postnatal...

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Bibliographic Details
Main Authors: Yun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth, Gina M. DeNicola
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cancer & Metabolism
Subjects:
PHGDH
Serine
Ceramide
Triacylglycerol
Mouse model
Online Access:http://link.springer.com/article/10.1186/s40170-020-00212-x

Internet

http://link.springer.com/article/10.1186/s40170-020-00212-x

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