The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α

The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α

Summary: Deviating from the normal karyotype dramatically changes gene dosage, in turn decreasing the robustness of biological networks. Consequently, aneuploidy is poorly tolerated by normal somatic cells and acts as a barrier to transformation. Paradoxically, however, karyotype heterogeneity drive...

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Bibliographic Details
Main Authors: Susana Simões-Sousa, Samantha Littler, Sarah L. Thompson, Paul Minshall, Helen Whalley, Bjorn Bakker, Klaudyna Belkot, Daniela Moralli, Daniel Bronder, Anthony Tighe, Diana C.J. Spierings, Nourdine Bah, Joshua Graham, Louisa Nelson, Catherine M. Green, Floris Foijer, Paul A. Townsend, Stephen S. Taylor
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718315055

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http://www.sciencedirect.com/science/article/pii/S2211124718315055

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