Non-invasive Motor Cortex Neuromodulation Reduces Secondary Hyperalgesia and Enhances Activation of the Descending Pain Modulatory Network

Non-invasive Motor Cortex Neuromodulation Reduces Secondary Hyperalgesia and Enhances Activation of the Descending Pain Modulatory Network

Central sensitization is a driving mechanism in many chronic pain patients, and manifests as hyperalgesia and allodynia beyond any apparent injury. Recent studies have demonstrated analgesic effects of motor cortex (M1) stimulation in several chronic pain disorders, yet its neural mechanisms remain...

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Bibliographic Details
Main Authors: Timothy J. Meeker, Michael L. Keaser, Shariq A. Khan, Rao P. Gullapalli, David A. Seminowicz, Joel D. Greenspan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neuroscience
Subjects:
motor cortex neuromodulation
pain model
secondary hyperalgesia
BOLD fMRI
event-related fMRI
human
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00467/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00467/full

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