Predominant HLA Alleles and Haplotypes in Mild Adverse Drug Reactions Caused by Allopurinol in Vietnamese Patients with Gout

Predominant HLA Alleles and Haplotypes in Mild Adverse Drug Reactions Caused by Allopurinol in Vietnamese Patients with Gout

Allopurinol (ALP) is commonly used as a drug for gout treatment. However, ALP is known to cause cutaneous adverse reactions (CARs) in patients. The HLA-B<sup>*</sup>58:01 allele is considered a biomarker of severe CAR (SCAR) in patients with gout, with symptoms of Stevens Johnson syndrom...

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Bibliographic Details
Main Authors: Chu Van Son, Nguyen Thi Hong Loan, Tran Huyen Trang, Le Xuan Thinh, Nguyen Ba Khanh, Le Thi Hong Nhung, Nguyen Van Hung, Tran Ngoc Que, Nguyen Van Lieu, Pham Dinh Tung, Nguyen Thi Van Anh, Nguyen Dinh Thang
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Diagnostics
Subjects:
gout
allopurinol
mild cutaneous adverse drug reactions (MCARs)
HLA-B<sup>*</sup>58:01 allele
one-locus haplotypes
HLA-A<sup>*</sup>02:01/HLA-A<sup>*</sup>24:02
Online Access:https://www.mdpi.com/2075-4418/11/9/1611

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https://www.mdpi.com/2075-4418/11/9/1611

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