NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo

NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo

Transcriptional coactivator PPAR γ coactivator (PGC)-1α and its splice variant N-terminal (NT)-PGC-1α mediate transcriptional regulation of brown adipose tissue (BAT) thermogenesis in response to changes in ambient temperature. PGC-1α is dispensable for cold-induced BAT thermogenesis as long as NT-P...

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Bibliographic Details
Main Authors: Jihyun Kim, Min Sung Park, Kyoungsoo Ha, Chulhong Park, Jisu Lee, Randall L. Mynatt, Ji Suk Chang
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Journal of Lipid Research
Subjects:
thermogenesis
beta-3 adrenergic receptor
fatty acid
N-terminal peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335355

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http://www.sciencedirect.com/science/article/pii/S0022227520335355

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