Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis

Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis

Brain l-glutamine (Gln) accumulation and increased activity of the NO/cGMP pathway are immediate consequences of acute exposure to ammonia. This study tested whether excess Gln may influence NO and/or cGMP synthesis. Intrastriatal administration of the glutaminase inhibitor 6-diazo-5-oxo-l-norleucin...

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Bibliographic Details
Main Authors: Wojciech Hilgier, Inez Fręśko, Emilia Klemenska, Andrzej Beręsewicz, Simo S. Oja, Pirjo Saransaari, Jan Albrecht, Magdalena Zielińska
Format: Article
Language:English
Published: Elsevier 2009-07-01
Series:Neurobiology of Disease
Subjects:
Striatum
Microdialysis
Glutamine
Arginine
Ammonia neurotoxicity
Cyclic GMP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000813

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http://www.sciencedirect.com/science/article/pii/S0969996109000813

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