Cryopreservation of microglia enables single-cell RNA sequencing with minimal effects on disease-related gene expression patterns

Cryopreservation of microglia enables single-cell RNA sequencing with minimal effects on disease-related gene expression patterns

Summary: Microglia play a key role in brain development, normal homeostasis, and neurodegenerative disorders. Single-cell technologies have led to important findings about microglia, with many animal model studies using single-cell RNA sequencing (scRNA-seq), whereas most human specimen studies usin...

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Bibliographic Details
Main Authors: Brenda Morsey, Meng Niu, Shetty Ravi Dyavar, Courtney V. Fletcher, Benjamin G. Lamberty, Katy Emanuel, Anna Fangmeier, Howard S. Fox
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:iScience
Subjects:
Molecular Neuroscience
Cellular Neuroscience
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221003254

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http://www.sciencedirect.com/science/article/pii/S2589004221003254

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