In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease

In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease

The positron emission tomography (PET) radioligand [11C]UCB-J binds to synaptic vesicle protein 2A (SV2A) and is used to investigate synaptic density in the living brain. Clinical studies have indicated reduced [11C]UCB-J binding in Alzheimer's disease (AD) and Parkinson's disease (PD) bra...

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Bibliographic Details
Main Authors: Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvänen
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:NeuroImage
Subjects:
Synaptic density
[11c]ucb-j
Positron emission tomography (PET)
Alzheimer's disease
Parkinson's disease
Transgenic mouse models
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811921005784

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http://www.sciencedirect.com/science/article/pii/S1053811921005784

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