Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase

Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase

There is substantial evidence that creatine administration exerts neuroprotective effects both in vitro and in vivo. The precise mechanisms for these neuroprotective effects however are as yet unclear. We investigated whether creatine administration could exert neuroprotective effects in mice defici...

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Bibliographic Details
Main Authors: Peter Klivenyi, Noel Y Calingasan, Anatoly Starkov, Irina G Stavrovskaya, Bruce S Kristal, Lichuan Yang, Bé Wieringa, M.Flint Beal
Format: Article
Language:English
Published: Elsevier 2004-04-01
Series:Neurobiology of Disease
Subjects:
Creatine
Creatine kinase
MPTP
Phosphocreatine
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610400004X

Internet

http://www.sciencedirect.com/science/article/pii/S096999610400004X

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