ETV6/RUNX1 Induces Reactive Oxygen Species and Drives the Accumulation of DNA Damage in B Cells

ETV6/RUNX1 Induces Reactive Oxygen Species and Drives the Accumulation of DNA Damage in B Cells

The t(12;21)(p13;q22) chromosomal translocation is the most frequent translocation in childhood B cell precursor-acute lymphoblastic leukemia and results in the expression of an ETV6/RUNX1 fusion protein. The frequency of ETV6/RUNX1 fusions in newborns clearly exceeds the leukemia rate revealing th...

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Bibliographic Details
Main Authors: Hans-Peter Kantner, Wolfgang Warsch, Alessio Delogu, Eva Bauer, Harald Esterbauer, Emilio Casanova, Veronika Sexl, Dagmar Stoiber
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800905

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http://www.sciencedirect.com/science/article/pii/S1476558613800905

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