Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents

Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents

A conformational restriction strategy was used to design and synthesize nine TZT-1027 analogues. 3-Aryl-azetidine moiety was used to replace phenylethyl group of TZT-1027 at the C-terminus. These analogues exhibited moderate to excellent antiproliferative activities, and the most potent compound 1a...

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Bibliographic Details
Main Authors: Qi Yan, Yujie Wang, Wei Zhang, Yingxia Li
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Marine Drugs
Subjects:
TZT-1027
azetidine
conformation restriction
antiproliferative activity
Online Access:http://www.mdpi.com/1660-3397/14/5/85

Internet

http://www.mdpi.com/1660-3397/14/5/85

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