ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes

ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes

Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activat...

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Bibliographic Details
Main Authors: Caodi Fang, Thomas D. Manes, Lufang Liu, Kevin Liu, Lingfeng Qin, Guangxin Li, Zuzana Tobiasova, Nancy C. Kirkiles-Smith, Manal Patel, Jonathan Merola, Whitney Fu, Rebecca Liu, Catherine Xie, Gregory T. Tietjen, Peter A. Nigrovic, George Tellides, Jordan S. Pober, Dan Jane-wit
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10041-2

Internet

https://doi.org/10.1038/s41467-019-10041-2

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