The allosteric modulation of complement C5 by knob domain peptides

The allosteric modulation of complement C5 by knob domain peptides

Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we previously isolated autonomous 3–6 kDa knob domains from bovine antibodies. Here, we show that binding of four kn...

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Bibliographic Details
Main Authors: Alex Macpherson, Maisem Laabei, Zainab Ahdash, Melissa A Graewert, James R Birtley, Monika-Sarah ED Schulze, Susan Crennell, Sarah A Robinson, Ben Holmes, Vladas Oleinikovas, Per H Nilsson, James Snowden, Victoria Ellis, Tom Eirik Mollnes, Charlotte M Deane, Dmitri Svergun, Alastair DG Lawson, Jean MH van den Elsen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
complement C5
bovine immunoglobulin
knob-domain peptides
Online Access:https://elifesciences.org/articles/63586

Internet

https://elifesciences.org/articles/63586

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