Panobinostat and its combination with 3-deazaneplanocin-A induce apoptosis and inhibit In vitro tumorigenesis and metastasis in GOS-3 glioblastoma cell lines

Panobinostat and its combination with 3-deazaneplanocin-A induce apoptosis and inhibit In vitro tumorigenesis and metastasis in GOS-3 glioblastoma cell lines

Aim: Glioblastoma is the most malignant primary brain tumor. The treatment consists of surgery, with or without radiotherapy, and temozolomide, with a life expectancy of 12–15 months after diagnosis. Glioblastoma is resistant to conventional antitumor therapies. In this work, we present a preliminar...

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Bibliographic Details
Main Authors: Javier de la Rosa, Alejandro Urdiciain, Juan Jesús Aznar-Morales, Bárbara Meléndez, Juan A Rey, Miguel A Idoate, Javier S Castresana
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Cancer Translational Medicine
Subjects:
3-Deazaneplanocin-A
enhancer of zeste homolog 2
epigenetics
histone deacetylases
panobinostat
Online Access:http://www.cancertm.com/article.asp?issn=2395-3977;year=2018;volume=4;issue=2;spage=39;epage=47;aulast=de

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http://www.cancertm.com/article.asp?issn=2395-3977;year=2018;volume=4;issue=2;spage=39;epage=47;aulast=de

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