FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis.

Focal adhesion kinase (FAK) is an intensely studied non-receptor tyrosine kinase with roles in cancer and other common human diseases. Despite the large interest in FAK, the in vivo contribution of FAK auto-phosphorylation site tyrosine (Y) 397 to FAK function is incompletely understood. To study FA...

Full description

Bibliographic Details
Main Authors: Joel B Heim, Cera A McDonald, Saranya P Wyles, Sindhuja Sominidi-Damodaran, Edwin J Squirewell, Ming Li, Catherine Motsonelidze, Ralph T Böttcher, Jan van Deursen, Alexander Meves
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6042779?pdf=render