Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness

Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness

Molecular targets to reduce muscle weakness and atrophy due to oxidative stress have been elusive. Here we show that activation of Sarcoplasmic Reticulum (SR) Ca2+ ATPase (SERCA) with CDN1163, a novel small molecule allosteric SERCA activator, ameliorates the muscle impairment in the CuZnSOD deficie...

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Bibliographic Details
Main Authors: Rizwan Qaisar, Shylesh Bhaskaran, Rojina Ranjit, Kavithalakshmi Sataranatarajan, Pavithra Premkumar, Kendra Huseman, Holly Van Remmen
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718307365

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http://www.sciencedirect.com/science/article/pii/S2213231718307365

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