High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal

High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal

Our objective was to establish a diabetes mellitus type 2 (DM2) model in rats using a high-fat diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control group (commercial feed), and HF-STZ group, (66.5%-commercial feed, 13.5%-lard, and 20%-sugar). STZ (40mg/kg i.p.) o...

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Bibliographic Details
Main Authors: DIEGO A. DE MAGALHÃES, WILLIAN T. KUME, FRANCYELE S. CORREIA, THAÍS S. QUEIROZ, EDGAR W. ALLEBRANDT NETO, MAÍSA P. DOS SANTOS, NAIR H. KAWASHITA, SUÉLEM A. DE FRANÇA
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2019-03-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
diabetes mellitus type 2 model
high-fat diet
streptozotocin
rats
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100615&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100615&lng=en&tlng=en

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