Integrated analysis of the aging brain transcriptome and proteome in tauopathy

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

Abstract Background Tau neurofibrillary tangle pathology characterizes Alzheimer’s disease and other neurodegenerative tauopathies. Brain gene expression profiles can reveal mechanisms; however, few studies have systematically examined both the transcriptome and proteome or differentiated Tau- versu...

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Bibliographic Details
Main Authors: Carl Grant Mangleburg, Timothy Wu, Hari K. Yalamanchili, Caiwei Guo, Yi-Chen Hsieh, Duc M. Duong, Eric B. Dammer, Philip L. De Jager, Nicholas T. Seyfried, Zhandong Liu, Joshua M. Shulman
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Molecular Neurodegeneration
Subjects:
MAPT
Tau
Alzheimer’s disease
Transcriptome
Proteome
Inflammation
Online Access:http://link.springer.com/article/10.1186/s13024-020-00405-4

Internet

http://link.springer.com/article/10.1186/s13024-020-00405-4

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