The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress.

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress.

Faithful DNA replication and repair requires the activity of cullin 4-based E3 ubiquitin ligases (CRL4), but the underlying mechanisms remain poorly understood. The budding yeast Cul4 homologue, Rtt101, in complex with the linker Mms1 and the putative substrate adaptor Mms22 promotes progression of...

Full description

Bibliographic Details
Main Authors: Raymond Buser, Vanessa Kellner, Andre Melnik, Caroline Wilson-Zbinden, René Schellhaas, Lisa Kastner, Wojciech Piwko, Martina Dees, Paola Picotti, Marija Maric, Karim Labib, Brian Luke, Matthias Peter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4743919?pdf=render

Internet

http://europepmc.org/articles/PMC4743919?pdf=render

Similar Items