Curvotaxis directs cell migration through cell-scale curvature landscapes

Curvotaxis directs cell migration through cell-scale curvature landscapes

The effect that microscale surface curvature has on cell migration has not been evaluated. Here the authors fabricate sinusoidal 3D surfaces and show that the cell nucleus and cytoskeleton cooperate to guide cells to concave valleys in a process they coin curvotaxis.

Bibliographic Details
Main Authors: Laurent Pieuchot, Julie Marteau, Alain Guignandon, Thomas Dos Santos, Isabelle Brigaud, Pierre-François Chauvy, Thomas Cloatre, Arnaud Ponche, Tatiana Petithory, Pablo Rougerie, Maxime Vassaux, Jean-Louis Milan, Nayana Tusamda Wakhloo, Arnaud Spangenberg, Maxence Bigerelle, Karine Anselme
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06494-6

Internet

https://doi.org/10.1038/s41467-018-06494-6

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