Synergistic Effect of Simultaneous versus Sequential Combined Treatment of Histone Deacetylase Inhibitor Valproic Acid with Etoposide on Melanoma Cells

Synergistic Effect of Simultaneous versus Sequential Combined Treatment of Histone Deacetylase Inhibitor Valproic Acid with Etoposide on Melanoma Cells

Melanoma is the most lethal form of skin cancer, which is intrinsically resistant to conventional chemotherapy. Combination therapy has been developed to overcome this challenge and show synergistic anticancer effects on melanoma. Notably, the histone deacetylase inhibitor, valproic acid (VPA), has...

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Bibliographic Details
Main Authors: Yueh-Ming Shyu, Lawrence Yu-Min Liu, Yung-Jen Chuang
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
synergistic effect
melanoma
histone deacetylase inhibitor (HDACi)
combination therapy
drug sequential order
Online Access:https://www.mdpi.com/1422-0067/22/18/10029

Internet

https://www.mdpi.com/1422-0067/22/18/10029

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