Dimerization Drives Proper Folding of Human Alanine:Glyoxylate Aminotransferase But Is Dispensable for Peroxisomal Targeting

Dimerization Drives Proper Folding of Human Alanine:Glyoxylate Aminotransferase But Is Dispensable for Peroxisomal Targeting

Peroxisomal matrix proteins are transported into peroxisomes in a fully-folded state, but whether multimeric proteins are imported as monomers or oligomers is still disputed. Here, we used alanine:glyoxylate aminotransferase (AGT), a homodimeric pyridoxal 5′-phosphate (PLP)-dependent enzyme, whose d...

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Bibliographic Details
Main Authors: Mirco Dindo, Giulia Ambrosini, Elisa Oppici, Angel L. Pey, Peter J. O’Toole, Joanne L. Marrison, Ian E. G. Morrison, Elena Butturini, Silvia Grottelli, Claudio Costantini, Barbara Cellini
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Personalized Medicine
Subjects:
alanine:glyoxylate aminotransferase
pyridoxal phosphate
peroxisome
peroxisomal import
dimerization
protein folding
Online Access:https://www.mdpi.com/2075-4426/11/4/273

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https://www.mdpi.com/2075-4426/11/4/273

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