Generation of a Transplantable Population of Human iPSC-Derived Retinal Ganglion Cells

Generation of a Transplantable Population of Human iPSC-Derived Retinal Ganglion Cells

Optic neuropathies are a major cause of visual impairment due to retinal ganglion cell (RGC) degeneration. Human induced-pluripotent stem cells (iPSCs) represent a powerful tool for studying both human RGC development and RGC-related pathological mechanisms. Because RGC loss can be massive before th...

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Bibliographic Details
Main Authors: Oriane Rabesandratana, Antoine Chaffiol, Antoine Mialot, Amélie Slembrouck-Brec, Corentin Joffrois, Céline Nanteau, Amélie Rodrigues, Giuliana Gagliardi, Sacha Reichman, José-Alain Sahel, Alain Chédotal, Jens Duebel, Olivier Goureau, Gael Orieux
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
retinal ganglion cells
induced pluripotent stem cells
retinal organoids
cell transplantation
optic nerve injury
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.585675/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.585675/full

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