Co-Administration of the CYP3A4 Inhibitor Diltiazem Counteracts Mitotane-Induced Clearance of Glucocorticoids and Antihypertensives in a Patient with Adrenocortical Carcinoma

Co-Administration of the CYP3A4 Inhibitor Diltiazem Counteracts Mitotane-Induced Clearance of Glucocorticoids and Antihypertensives in a Patient with Adrenocortical Carcinoma

ABSTRACT: Objective: We report a case of adrenal insufficiency and resistant hypertension in a patient with adrenocortical cell carcinoma (ACC) under mitotane treatment, in which a cytochrome P450 (CYP)3A4 inhibitor, diltiazem, successfully reduced mitotane-induced clearance of glucocorticoids and a...

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Main Authors: Isao Minami, MD, PhD, Takanobu Yoshimoto, MD, PhD, Kazutaka Tsujimoto, MD, Keiko Homma, PhD, Tomonobu Hasegawa, MD, PhD, Yoshihiro Ogawa, MD, PhD
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:AACE Clinical Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2376060520303825

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http://www.sciencedirect.com/science/article/pii/S2376060520303825

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