Spatiotemporal and Functional Heterogeneity of Hematopoietic Stem Cell-Competent Hemogenic Endothelial Cells in Mouse Embryos

Spatiotemporal and Functional Heterogeneity of Hematopoietic Stem Cell-Competent Hemogenic Endothelial Cells in Mouse Embryos

Hematopoietic stem cells (HSCs) are derived from hemogenic endothelial cells (HECs) during embryogenesis. The HSC-primed HECs increased to the peak at embryonic day (E) 10 and have been efficiently captured by the marker combination CD41–CD43–CD45–CD31+CD201+Kit+CD44+ (PK44) in the aorta-gonad-meson...

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Bibliographic Details
Main Authors: Yun-Qiao Li, Yandong Gong, Siyuan Hou, Tao Huang, Haizhen Wang, Di Liu, Yanli Ni, Chaojie Wang, Junliang Wang, Jun Hou, Ruichuang Yang, Jing Yan, Guangyu Zhang, Bing Liu, Yu Lan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hematopoietic stem cells
hemogenic endothelial cells
heterogeneity
developmental hematopoiesis
single-cell RNA-sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.699263/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.699263/full

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