Co-Stimulation of Purinergic P2X4 and Prostanoid EP3 Receptors Triggers Synergistic Degranulation in Murine Mast Cells

Co-Stimulation of Purinergic P2X4 and Prostanoid EP3 Receptors Triggers Synergistic Degranulation in Murine Mast Cells

Mast cells (MCs) recognize antigens (Ag) via IgE-bound high affinity IgE receptors (FcεRI) and trigger type I allergic reactions. FcεRI-mediated MC activation is regulated by various G protein-coupled receptor (GPCR) agonists. We recently reported that ionotropic P2X4 receptor (P2X...

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Bibliographic Details
Main Authors: Kazuki Yoshida, Makoto Tajima, Tomoki Nagano, Kosuke Obayashi, Masaaki Ito, Kimiko Yamamoto, Isao Matsuoka
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
extracellular atp
p2x4 receptor
prostaglandin e<sub>2</sub>
ep3 receptor
bone marrow-derived mast cell
mast cell degranulation
ca<sup>2+</sup> influx
pi3 kinase
Online Access:https://www.mdpi.com/1422-0067/20/20/5157

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https://www.mdpi.com/1422-0067/20/20/5157

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