Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration

Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration

Abstract Background Age-related macular degeneration (AMD) is a result of degeneration/damage of the retinal pigment epithelium (RPE) while retinitis pigmentosa (RP), an inherited early-onset disease, results from premature loss of photoreceptors. A promising therapeutic approach for both is the rep...

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Bibliographic Details
Main Authors: Harshini Surendran, Swapna Nandakumar, Vijay Bhaskar Reddy K, Jonathan Stoddard, Varsha Mohan K, Pramod K. Upadhyay, Trevor J. McGill, Rajarshi Pal
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Induced pluripotent stem cells
Retinal pigment epithelium
Photoreceptor
Age-related macular degeneration
Retinitis pigmentosa
Online Access:https://doi.org/10.1186/s13287-021-02134-x

Internet

https://doi.org/10.1186/s13287-021-02134-x

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