Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells

Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells

Elevated epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) signaling are known to contribute to the malignant properties of glioblastoma multiforme (GBM), which include uncontrolled cell proliferation and evasion of apoptosis. Small molecule inhibitors that target the...

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Bibliographic Details
Main Authors: Ravi D. Rao, Ann C. Mladek, Jeffrey D. Lamont, Jennie M. Goble, Charles Erlichman, C. David James, Jann N. Sarkaria
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
epidermal growth factor receptor
signal transduction
rapamycin
glioblastoma
4EBP1
AM
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605801162

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http://www.sciencedirect.com/science/article/pii/S1476558605801162

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