MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset

MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset

Seizures are bursts of excessive synchronized neuronal activity, suggesting that mechanisms controlling brain excitability are compromised. The voltage-gated potassium channel Kv4.2, a major mediator of hyperpolarizing A-type currents in the brain, is a crucial regulator of neuronal excitability. Kv...

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Bibliographic Details
Main Authors: Christina Gross, Xiaodi Yao, Tobias Engel, Durgesh Tiwari, Lei Xing, Shane Rowley, Scott W. Danielson, Kristen T. Thomas, Eva M. Jimenez-Mateos, Lindsay M. Schroeder, Raymund Y.K. Pun, Steve C. Danzer, David C. Henshall, Gary J. Bassell
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
microRNA
Kv4.2
seizure
excitotoxicity
miR-324-5p
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311706

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http://www.sciencedirect.com/science/article/pii/S2211124716311706

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